Football odds for the NFL and college football odds look similar when you see them at a sportsbook. The way you handicap and bet those odds are different though because the NFL and college football are different. There are many factors that separate college football odds from NFL odds.
Football odds in the NFL are definitely more popular than college football odds. This means more than half of the money wagered at sportsbooks comes from the public in NFL odds. This is totally different from college football where the wise guys are more prevalent than the public. College football is still a public sport, but nothing compares to the NFL. If a sportsbook gets one sided on a college football game it is more likely that it is from wise guy money. In the NFL a game can get one-sided by either wise guy or public money.
Another difference between NFL odds at sportsbooks and college football odds is the fact that key numbers don't mean nearly as much in college football. The numbers of 3, 6, 7, 10, and 14 are just not that meaningful in college football odds. In reality the only number that is a big key in NFL odds is 3, but people still think the other ones have some importance. Another difference is the fact that you rarely see more than a 14-point favorite in the NFL. You see huge favorites of 20, 30, or 40 points in college football nearly every week.
Another difference between NFL betting at sportsbooks and college football odds is the amount of turnover in players that you see in college football. In the NFL you do have free agency but many of the players remain on the same teams year after year. That is not the case in college football where players are constantly changing. Another difference in college and pro football odds is the fact that injuries are much better known in the NFL than they are in college football. Getting information out of some of the college teams is very difficult and when you begin to look at some of the smaller colleges, it is even tougher.
There are definitely differences between NFL and college football at sportsbooks. The football odds in college are more unpredictable, the information more scarce, and overall everything is more unknown.